#109 How To Boost NAD Levels To Fight Inflammation, Improve Recovery, and Slow Aging | Dr. Charles Brenner
2/9/20261 hr 59 min
Get access to more than 200 episodes of my premium podcast (The Aliquot) when you sign up as a FoundMyFitness Premium Member
Many symptoms attributed to aging are also consistent with chronic inflammatory stress and impaired NAD metabolism. Dr. Charles Brenner explains the mechanisms, the human data, and what interventions actually move the needle. He also cuts through the crowded world of NAD boosters, including oral NAD pills, NMN, NR, and NAD IV drips, clarifying what actually raises NAD in humans and what emerging research suggests about NR for lowering inflammation and improving recovery.
Timestamps:
(00:00) I...
Clips
Transcript preview
First 90 secondsRhonda Patrick· Host0:00
Today my guest is Dr. Charles Brenner, who is a distinguished biochemist who made the groundbreaking discovery of nicotinamide riboside. This is a potent vitamin precursor to NAD. This is a molecule that is fundamental to cellular energy, DNA repair, gene regulation, and also immunity. Dr. Brenner is recognized globally as the leading expert on NAD biology, so it is a real treat to have him here today. This episode is an in-depth discussion on all things NAD. In this episode, Dr. Brenner and I discuss why nicotinamide riboside is uniquely positioned among NAD precursors for effectively boosting NAD levels. It has robust clinical evidence supporting anti-inflammatory benefits at doses between 500 to 1,000 milligrams a day. We discuss the significant role NAD plays in conditions driven by chronic inflammation, including obesity, insulin resistance, peripheral artery disease, and age-related cognitive decline. And we also talk a little bit about the surprising implications of nicotinamide riboside and NAD for exercise recovery. We discuss how inflammation profoundly taxes the NAD system across a variety of different tissues. It's not merely just the blood, but also other organs as well, highlighting really the necessity of addressing all of these underlying lifestyle factors that affect inflammation. We also discuss practical guidance on supplement timing, particularly