#439: Reclaiming Metabolism: The SECRET Molecule Transforming Women's Health (Belly Fat, Brain Power & Beyond) With Siobhan Mitchell PhD
5/19/20261 hr 6 min
Today, I’m joined by the insightful Siobhan Mitchell PhD, a leading expert on women’s health, mitochondria, and metabolic resilience. In our conversation, Siobhan reveals why so many women in their 30s and 40s feel like their metabolism is suddenly “broken,” and unpacks the real science behind what’s happening beneath the surface—especially as our hormones begin to shift. Episode Timestamps: Introduction and host welcome ... 00:00:00 Introducing Speaker B and focus on women’s health ... 00:04:30 Growing interest in women’s health and clinical gaps ... 00:05:12 Body composition and metabolic changes in perimenopause ... 00:06:01 Hormonal shifts—not a broken metabolism ... 00:09:21 Addressing the root cause versus band-aids like GLP-1 ... 00:11:10 What’s happening beneath the surface in early perimenopause ... 00:12:40 Role of estrogen in appetite, glucose, and fat storage ... 00:13:12 Visceral fat, inflammation, and accelerated aging ... 00:15:02 Estrogen’s connection to mitochondrial function ... 00:16:15 Brain, muscle, and cognitive declines with estrogen loss ... 00:16:44 Environmental and mitochondrial factors in PCOS ... 00:21:09 Shift to belly fat and why fat storage changes ... 00:22:58 Mitochondria, immune system, and autoimmunity in women ... 00:29:16 Phytoestrogens, soy, and S-equol as hormone alternatives ... 00:32:37 S-equol’s benefits: metabolic, bone, and brain health ... 00:35:50 Soy fears, GMOs, and the purity of S-equol ... 00:46:25 Microbiome, Bifidobacterium breve, and estrogen recycling ... 00:49:18 GLP-1s versus supporting the root cause ... 00:53:01 Optimizing estrogen signaling for health span and menopause timing ... 00:55:20 When to use S-equol: timing and benefits ... 00:55:54 Reversing visceral fat and lifestyle factors ... 01:03:28 Our Amazing Sponsors: Manukora Honey - A simple upgrade to your daily routine, this Manuka honey delivers antioxidants, prebiotics, and naturally occurring MGO that you won’t get from regular sweeteners; head to http://manukora.com/natniddam to save up to 31% plus $25 in free gifts with the Starter Kit. Mitopure Gummies by Timeline - These clinically researched gummies support mitophagy to help renew your mitochondria and boost cellular energy, giving you a stronger biological foundation for resilience—visit http://timeline.com/nat20 to get 20% off. Daily Gut Detox by Just Thrive Health – A gentle, science-backed detox powered by clinically proven immunoglobulins that bind and remove toxins while supporting your gut, immune system, and digestion—without harsh flushing or discomfort. Visit JustThriveHealth.com/NAT20 and use code NAT20 for 20% off your order, risk-free. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode
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First 90 secondsNathalie Niddam· Host0:00
[gentle music] Welcome to Longevity. I'm your host, Natalie Kniddom. I'm a nutritionist, a human potential and epigenetic coach, and I created this podcast to bring you the latest ways to take control of your health and longevity. We cover it all, from new technology and ancestral health practices, to personalized interventions, and a very special interest of mine, peptides and bioregulators. Enjoy the show. Welcome back to the show. I'm Natalie Kniddom, your host. Today's conversation goes into something that sounds almost too good to be true: a compound that doesn't just impact metabolism, but may also cross the blood-brain barrier and influence how well your brain actually functions. I'm joined by Siobhan Mitchell. We get into what this molecule, C-Quol, is doing inside the body, why it's getting attention in metabolic health circles, and what the early research is hinting at when it comes to cognitive performance. Now, if you wanted to give it a try after you listen to the episode, what you need to do is visit mitoq.com and use code NAT to get an extra 10% off at checkout. Next up, we'll thank a couple sponsors, and then we're off. But before we do that, I actually have a favor to ask you. Should you go looking for me on Instagram and not find me at my usual handle, which is @nataliekniddom, please go look for me at longevitywithnat. It seems that my account got caught up in a bit