GLP-1 Side Effects, Risks, And Who Should Actually Be Using It | Dr. Christle Guevarra
4/21/20261 hr 23 min
We are living through one of the most significant shifts in medicine in generations, and most people don’t fully understand what it means. Dr. Christle Guevarra joins me to zoom out on the entire GLP-1 landscape; from the drug’s origins as a modest diabetes treatment in 2005 to today’s third-generation medications still moving through clinical trials, and what all of it means for the future of obesity, performance, and longevity.
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⏰Timestamps:
00:00 Intro of Show
06:48 Changes in the Fat Loss Landscape
06:54 Engagement in Competitive Powerlifting
11:29 Perspectives on GLP-1 Medication
26:10 Perimenopause Journey
27:13 Topamax
28:03 Urosepsis
30:23 Weight Loss Programming
31:43 Patients' Decision to Take GLP-1
37:44 Risks and Effects on Taking GLP-1
38:10 Pancreatitis
41:40 Fen-Phen (Fenfluramine/phentermine) / Ephedra
45:59 Who Should Not Take GLP-1?
49:24 Proper Nutrition to Support Taking GLP-1
52:14 Recommendation for the New Dietary Guidelines
59:01 Residency and Sports Medicine Fellowship
1:02:38 Are Athletes Recommended to Take GLP-1?
1:08:49 Lack of Randomized, Controlled Trials for Peptides
1:10:38 Key Take-away's from Dr. Christle
1:13:24 Should Women Weigh Themselves?
1:21:02 Should Women Lift Weights?
1:21:55 What's Next for Dr. Christle?
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Clips
Transcript preview
First 90 secondsChristle Guevarra· Guest0:00
Throughout various parts of my life, since I can't figure out this whole calories, fat loss thing down, I am just going to focus on lifting weights and find, you know, joy in taking ownership of the fact that I can lift something heavy. And it gave me a lot of confidence that I couldn't get from hunger, fat loss, you know, losing weight.
Gabrielle Lyon· Host0:23
We are alive at a time that the landscape of medicine is changing. GLP-1s have been around for a long time, but they haven't been used, they have not been FDA-approved for weight loss. There has never been something more effective than these medications.
Christle Guevarra· Guest0:39
I feel like there's still the, a lot of a disconnect, especially with the way medicine traditionally is set up. Sometimes it can get a little hard to help with the behavioral change aspect of the GLP-1 use. And so I find that there are still a lot of people who are struggling with, how do I eat? How do I exercise? It seems like we could do a little bit better in providing that support when it comes to the behavioral change part.
Gabrielle Lyon· Host1:06
What are some of the biggest challenges that they come in and say they've struggled with?
Christle Guevarra· Guest1:09
When somebody's eating to get in the, as much fiber to feel satiated and they still don't, I have to wonder, is that...
Gabrielle Lyon· Host1:17
[gentle music] Dr. Crystal, welcome to the show.
Christle Guevarra· Guest1:28
Thank you so much for having