Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett
7/2/202640 min
In this Huberman Lab Essentials episode, my guest is Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine, and an expert in hormone optimization. We discuss science-based tools for optimizing male hormones across the lifespan, including the role of bloodwork, nutrition, and exercise in supporting healthy hormone levels. We also discuss testosterone therapy, hair loss, prostate health, and supplements such as creatine, L-carnitine, Tongkat Ali, and Fadogia agrestis.
Read the show notes at hubermanlab.com.
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Timestamps
(00:00:00) Kyle Gillett
(00:00:20) Male Hormone Optimization, Testosterone, Tool: Blood Tests
(00:02:17) Diet & Hormone Health, Diary, Vitamin D, Fiber
(00:05:36) Caloric Restriction & Testosterone
(00:06:44) Lifestyle Pillars: Stress, Life Purpose
(00:07:56) Sponsor: LMNT
(00:09:28) Exercise & Hormone Health
(00:10:32) Testosterone Replacement Therapy (TRT) & Young Adults
(00:12:05) Supplements for Testosterone, Creatine & Hair Loss; Betaine, Doses
(00:15:50) L-Carnitine, Forms, Dose, TMAO, Garlic & Berberine
(00:19:02) Vitamin D, Boron
(00:20:43) Tongkat Ali (Longjack)
(00:23:34) Sponsor: AG1
(00:24:53) Fadogia Agrestis
(00:26:49) Testosterone Therapy, Dose; Side Effects
(00:31:24) Clomiphene, SERM & Testosterone
(00:33:58) Sponsor: David
(00:35:16) Alcohol, Aromatase & Testosterone
(00:36:09) Prostate Health & Tadalafil, Nighttime Urination
(00:38:10) Hair Loss, Caffeine, Finasteride, Dutasteride
(00:40:13) Acknowledgements
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Clips
Transcript preview
First 90 secondsAndrew Huberman· Host0:00
Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent and actionable science-based tools for mental health, physical health, and performance. I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. And now for my discussion with Dr. Kyle Gillett. Dr. Gillett, great to have you back.
Kyle Gillett· Guest0:22
Great to be back. Thank you.
Andrew Huberman· Host0:23
I'd like to begin with a question about what all males ought to do in order to optimize their hormones. What should they be doing and what should they avoid doing if the goal is to have a long arc of healthy hormone optimization throughout the lifespan?
Kyle Gillett· Guest0:38
There's many things that you should do. An analogy that I often make is when there's a brand-new car that comes off the assembly line, you do a full scope of diagnostic workup, hook it up to the computer, and I think we should do the same thing with humans as well. During puberty, you know, obviously you're a functioning human, but, uh, I would say there's still development, and I think that the, the human always develops. I don't think development ever ends. But you want to monitor that progress across a person's h- lifespan.
Andrew Huberman· Host1:08
What do you think are the key things to look for in blood work? I mean, ev- testosterone is always the topic that comes up in the context of male hormone optimization, but certainly there are a lot of other hormones that are important as well.
Kyle Gillett· Guest1:19
Mm-hmm. And with testosterone, you want to get either testosterone and a SHBG or a free testosterone.
Andrew Huberman· Host1:25
Could you define SHBG for our listeners, please?
Kyle Gillett· Guest1:27
It is sex hormone binding globulin. It is the protein