The Curbsiders Internal Medicine Podcast#523 Hotcakes: Left Atrial Appendage Closure vs AC for Afib, Apixaban vs Rivaroxaban for VTE, Intensive LDL Targeting, GLP1s and Substance Use Disorders, and moreNon-inferiority margin red flags
6:49–8:07 · 78s
Guest Dr. Shani Herzig dissects the CHAMPION AF trial, arguing the chosen 4.8% non-inferiority margin could mask clinically meaningful increases in stroke and bias the trial toward a positive result.