The Curbsiders Internal Medicine Podcast#523 Hotcakes: Left Atrial Appendage Closure vs AC for Afib, Apixaban vs Rivaroxaban for VTE, Intensive LDL Targeting, GLP1s and Substance Use Disorders, and more

Crossover flips the bias

11:15–12:18 · 64s

Shani explains why heavy crossover can falsely support non-inferiority, contrasting how crossover affects superiority versus non-inferiority trials.

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