#420: Spermidine UNLOCKED: Reverse Aging, Boost Immunity & Thrive After 40 With Leslie Kenny
3/13/20261 hr 37 min
Today, I'm joined by the inspiring Leslie Kenny, Oxford-based longevity expert and a living example of turning adversity into vitality. After being told at 39 that she had lupus, rheumatoid arthritis, and just five years to live, Leslie defiantly forged a new path—reversing her diagnoses, restoring her thyroid health, and even welcoming a healthy baby girl at 43. Her story is a testament to the power of questioning the status quo, honoring the wisdom within our bodies, and refusing to accept decline as inevitable.
Leslie has a generous offer for you, when you visit oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout you'll get 20% off.
Episode Timestamps:
Welcome, show intro, and overview ... 00:00:00
Leslie Kenny's health journey and reversing disease ... 00:00:30
Biological vs. chronological age and the immune system ... 00:04:55
Impact of trauma and stress on aging ... 00:11:51
Overcoming prognosis: lifestyle and scientific interventions ... 00:18:02
Diet, tracking, and removing triggers ... 00:22:21
The overlooked importance of thyroid health ... 00:32:23
Dangers of overdoing fasting and hormesis ... 00:40:21
Autophagy basics and the cellular cleanup crew ... 00:44:06
Spermidine's role, sourcing, and supplement quality ... 01:10:19
Optimizing longevity habits and daily routines ... 01:29:44
Our Amazing Sponsors:
Tro Zzz by Troscriptions – A fast-acting sleep troche that dissolves in your cheek and combines melatonin with compounds like honokiol, adenosine, cordycepin, CBD, CBN, and 5-HTP to support deep, restorative sleep when travel, stress, or late workouts throw things off. Head to troscriptions.com and use code NAT10 for 10% off your first order.
BEAM Minerals - Low energy often starts in the mitochondria. Support cellular energy with a bioavailable liquid mineral supplement — and get 20% off at beamminerals.com with code NAT20.
Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to http://www.profound-health.com/?Aff=Longevity15 and use code NAT15 for 15% off your first order.
Nat's Links:
Clips
Transcript preview
First 90 secondsNathalie Niddam· Host0:00
[gentle music] Welcome to Longevity. I'm your host, Natalie Needham. I'm a nutritionist, a human potential and epigenetic coach, and I created this podcast to bring you the latest ways to take control of your health and longevity. We cover it all, from new technology and ancestral health practices, to personalized interventions, and a very special interest of mine, peptides and bioregulators. Enjoy the show. [gentle music] Hi, I'm Natalie Needham, your host. After facing infertility, autoimmune disease, and a life-limiting diagnosis, Leslie Kenney began questioning everything, from conventional treatment models to how lifestyle, grief, and immune regulation shape long-term health. An Oxford-based longevity expert and graduate of UC Berkeley and Harvard, Leslie personally reversed lupus, rheumatoid arthritis, and infertility, later giving birth naturally at age 43. We explore how silent inflammation accelerates aging, why thyroid health is often the missing link, and the role of spermidine in activating autophagy. It's a deeply personal story woven into some of the most compelling longevity science we've covered on this show. Leslie has a generous offer for you when you visit oxfordhealthspan.com/bionat20, and you get to use code BIONAT20 at checkout to get 20% off. Next, we'll thank two of the sponsors who helped make this show possible, and then we get to dive