166. Carolina Reis de Oliveira: The Missing Link Between Skin and Longevity
5/21/202657 min
If you think your skincare routine is protecting your skin, this conversation may make you look at your bathroom shelf differently. You've been taught to treat your skin like something cosmetic, something you maintain for how it looks. But your skin is your largest organ, it has its own biological age, and if you are not supporting it properly, it can become a constant source of inflammation and damage that goes far beyond appearance.
We dive deeper into this in Extend with Carolina Reis de Oliveira, PhD. We also break down why most skincare products are not built to target the biology of aging, how senescent cells drive visible and invisible skin aging, and how OS-01, discovered through machine learning, is designed to slow the spread of these dysfunctional cells so you can actually support your skin as part of your longevity strategy.
Carolina Reis de Oliveira, PhD, is a stem cell biologist, tissue engineer, and co-founder and CEO of OneSkin. She has spent over a decade researching cellular aging, building human skin models in the lab, and developing epigenetic clocks to measure biological skin age, with her work on OS-01 validated through peer-reviewed research, making her one of the leading voices translating longevity science into real-world applications for skin.
For a limited time, you can try OneSkin for 15% off with code EXTEND at oneskin.co/EXTEND That's 15% off oneskin.co with code EXTEND
What's Discussed:
(2:02) Why OneSkin started by asking what actually targets skin aging at the cellular level.
(4:02) How popular anti-aging products can cause inflammation and damage.
(9:25) The three main drivers of skin aging: senescence, inflammation, and collagen breakdown.
(11:24) Why UV exposure is responsible for most visible skin aging.
(21:33) How OS-01 was discovered through machine learning and peptide screening.
(26:33) Why too many actives can overwhelm the skin instead of helping it.
(32:58) How aging skin can contribute to inflammation inside the body.
(37:12) How skin biological age can be measured with epigenetic clocks.
Listen to this episode of Extend with Darshan Shah, MD on Apple Podcasts or Spotify to understand why skin is not just cosmetic, what actually drives skin aging at the cellular level, and how to start treating your skin like the longevity organ it really is.
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Learn more about Dr. Darshan Shah:
Website: drshah.com
Clinic: next-health.com
Instagram: darshanshahmd
Learn more about OneSkin:
Website: www.oneskin.co/
Instagram: @oneskin.co
TikTok: @oneskin.co
Clips
Transcript preview
First 90 secondsDarshan Shah· Host0:00
[gentle music] Welcome to Extend, with me, Dr. Darshan Shah, a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your health span. Having become one of the youngest doctors in the country at the age of 21, and trained and board-certified at the Mayo Clinic, I've accumulated three decades of practice as a board-certified surgeon and longevity expert. Over that time, I've discovered that a mere 20% of health knowledge yields 80% of the results when it comes to your health span. We are living in a new era where we are creating a new healthcare system no longer focused on disease management, but achieving optimal health and vitality. Join me as I interview world-renowned experts, offering you a step-by-step guide to proactively avoid disease, and most importantly, extend your health span. Are you treating the symptoms of skin aging, or are you addressing its root cause at a cellular level? This episode with Dr. Carolina Reis, CEO and co-founder of OneSkin, reveals how her team of scientists revolutionized skincare by focusing in on cellular senescence. We discover how their groundbreaking peptide is the first scientifically validated ingredient to specifically target and reverse biological age by clearing out senescent skin cells. Dr. Reis shares the fascinating journey from growing mini organs to meticulously testing thousands of compounds on skin samples that were grown in the lab, how uncovering most