GABA, Methylene Blue, Mitochondria and The Parasympathetic Edge with Dr Scott Sherr
3/24/20261 hr 7 min
In this episode, Dr. Jockers sits down with Dr. Scott Sherr to break down why so many people are stuck in fight or flight and what it's really doing to your brain and body. You'll learn how GABA acts as the "brake system" for your nervous system and why low levels are linked to anxiety, poor sleep, and burnout. They also unpack why fixing stress is not just mental, but deeply biological.
You'll get a clearer picture of what's actually going on inside your cells when you feel exhausted, wired, or mentally foggy. Dr. Sherr explains how your mitochondria play a central role in all of it and why supporting them can change how you feel day to day. They also talk about tools like methylene blue and oxygen therapy, and when they can actually make a difference.
They also get into why constantly pushing harder isn't the answer, and how being able to slow your system down can actually improve your performance. You'll hear what it really means to shift into a parasympathetic state and why so many people struggle to get there. It may change the way you think about stress, recovery, and what your body actually needs.
In This Episode:
00:24 Show Intro and Guest
05:04 Sympathetic Spiral of Doom Explained
08:40 The Parasympathetic Edge
12:32 GABA Gas and Brakes System
15:22 Gut Inflammation and GABA Connection
16:49 Safer Ways to Support GABA
19:55 Alcohol, Benzos and Dependence
22:26 Why Calming Alone Can Backfire
27:13 Mitochondrial Dysfunction Root Causes
30:29 Methylene Blue as an Energy Bridge
32:40 Methylene Blue Controversies
36:20 SSRI Safety Considerations
37:47 High Dose Clinical Use
38:27 Versus CoQ10, PQQ and Creatine
41:29 Hyperbaric Oxygen Basics
43:29 Acute vs Chronic Protocols
46:01 Chamber Pressure Differences
47:17 Health Optimization Medicine Explained
49:55 Trauma and the Sympathetic Loop
55:26 Vagus Nerve Tools and Limits
01:02:54 Performance, Recovery and Closing Insights
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"Most GABA is made in the brain from glutamate using magnesium and vitamin B6. If you're deficient, your nervous system struggles to slow down."
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Connect with Dr. Scott Sherr:
- Website: https://drscottsherr.com/
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- Website – https://drjockers.com/
If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/
Clips
Transcript preview
First 90 secondsScott Sherr· Guest0:00
We used to think that depression, for example, was a serotonin deficiency, and that's why we were giving serotonergic drugs or drugs that increase serotonin like SSRIs, like Paxil and Prozac and things like that. But we now know that there is no evidence that serotonin levels are lower in people with depression versus the people that don't have depression. But their GABA levels, by the way, are lower. GABA deficiency is absolutely associated with depression.
David Jockers· Host0:23
Well, welcome back to the podcast. Our topic today is GABA optimization, mitochondrial recoupling, and the parasympathetic edge with my guest, Dr. Scott Sherr. We're gonna talk all about the importance of GABA, the brakes in your brain. We're gonna talk about why humans are stuck in fight or flight, in the sympathetic spiral of doom, and we're gonna talk about the parasympathetic edge, how this enhances our, our healing, our recovery, our energy, our brain function. We're gonna talk about mitochondrial recoupling and key compounds that can help to activate the mitochondria and recouple it for optimal energy production. We're gonna talk about how to leverage oxygen in our system for better energy production, how to rewire the nervous system and pull our body from stress and survival to adapt to really health and thriving. And so a little bit about Dr. Scott. He's a board-certified internal medicine physician, uh, certified to practice health optimization medicine, and a hyperbaric oxygen therapy specialist.