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David Reich – Why the Bronze Age was an inflection point in human evolution

5/8/20262 hr 13 min

David Reich is back.

He and collaborator Ali Akbari just published a paper that overturns a long-standing consensus about human evolution — that natural selection has been dormant in our species since the agricultural revolution.

By scaling ancient DNA sequencing and developing a new statistical method, they found that selection has actually sped up.

Selection went especially bonkers during the Bronze Age (around 3,000 years ago).

That’s when gene frequencies for everything from immune function to body fat to intelligence were most in flux.

Over the last 10,000 years, selection pushed the genetic predictor of cognitive performance up by roughly a full standard deviation — most of it between 4,000 and 2,000 years ago.

After we finished recording, David sketched out on a whiteboard his new heretical model about who the Neanderthals really were. Luckily, I took out my iPhone and managed to record it.

He thinks the standard story (that Neanderthals are some separate archaic lineage we interbred with a little) just doesn’t fit the evidence. Instead, he proposes that Neanderthals are essentially genetically-swamped modern humans.

A small population somewhere around the Caucasus invented Middle Stone Age technology roughly 300,000 years ago and expanded outward. The ones that moved into Europe interbred with local archaic humans, got genetically swamped, and became Neanderthals. The same expansion went into Africa, met much more diverged archaic Africans, and that mixture became us.

This means Neanderthals and modern humans share the same cultural ancestry — the only difference is which archaic humans they mixed with afterward.

David is a brilliant and rigorous scholar. It was a real delight to learn from him again.

Watch on YouTube; read the transcript.

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Timestamps

(00:00:00) – Ancient DNA suggests strong selection over last 10,000 years

(00:15:45) – Natural selection intensified during the Bronze Age

(00:35:02) – Why didn’t evolution max out intelligence?

(00:57:21) – Evolution is limited by time, not population size

(01:09:02) – Why no farming before the Ice Age?

(01:17:13) – The Neanderthal puzzle David can’t stop thinking about

(01:54:10) – The methodology behind this breakthrough

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Transcript preview

First 90 seconds
  1. Dwarkesh Patel· Host0:00

    I am back with David Reich, who is a professor of ancient DNA at Harvard. How do you describe what it is that you, um, you study?

  2. David Reich· Guest0:08

    I'm a geneticist.

  3. Dwarkesh Patel· Host0:10

    Oh, yeah.

  4. David Reich· Guest0:10

    And I work on human history and how people, uh, relate, uh, ancient people relate to each other and people living today.

  5. Dwarkesh Patel· Host0:17

    Great. Um, and so we did an interview, uh, was it two years ago at this point? Which, um, ended up being one of the most popular interviews I've ever done. I think people just found really compelling that there's so much about human history we don't know and are just learning about now as a result of the kinds of techniques that your lab is using. And, um, you have a new preprint, uh, that, um, uh, that's very exciting, and I wanted to talk to you about it. Um, so let's begin. What... Can you, can you t- give me a little bit of context on what we're talking about today?

  6. David Reich· Guest0:45

    Well, well, the dream was that when this field started, this ancient DNA field started, uh, more than 16 or 17 years ago, that we were gonna learn a lot about biology, learn about how people's biology changed over time by getting DNA out of ancient human remains and tracking changes over time. And that dream has really not been realized, uh, since the beginning of this field. So while the field's been a big success with regard to learning about human history, it's resulted in, um, surprising findings about human migrations, people not being descended from the people who lived in the same place hundreds or thousands or tens of thousands of years before, and mixture being common in human history, sex bias processes being common in human history,

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