Are Psychedelics the Key to Living Forever? (ft. Bryan Johnson)
3/26/202638 min
(0:00) David Friedberg intros Bryan Johnson
(0:54) Why Bryan Johnson did 5-MeO-DMT
(12:56) What brain scans actually show
(18:36) Psychosis, bad trips, and life-altering decisions
(26:23) The next frontier: organoids and gene therapy
(33:26) GLP-1s, abundance, and human optimization
(35:35) The longevity drug nobody's talking about?
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Showing 10 of 12Transcript preview
First 90 secondsDavid Friedberg· Host0:00
Brian Johnson, thanks for being here.
Bryan Johnson· Guest0:01
Yeah, it's good to see you.
David Friedberg· Host0:02
How are you feeling? Maybe just share with us what you did a few days ago and- Yeah ... we'll get into it.
Bryan Johnson· Guest0:06
I did, um, a, I did 5-MeO-DMT, which is the most powerful psychedelic on the planet. Uh, somewhere between five and ten times more powerful than DMT. And so, yeah, I- It's... So it's been 48 hours. I'm still learning how to talk about it.
David Friedberg· Host0:23
I'm going all in. [upbeat music] You know what many of the biggest tech CEOs and VCs have in common? They sleep on the Pod by Eight Sleep. It's become tech's favorite way to sleep, and for good reason. A cover that goes on any mattress, cools it down to 55 degrees, and uses AI to adjust your temperature all night. Up to 34% more deep sleep. No wearable needed. Go to eightsleep.com/allin and use code ALLIN for up to $350 off your Pod purchase today. All in. Before we get into your experience, why did you choose to do it?
Bryan Johnson· Guest0:57
Two things. One, mostly as a longevity experiment. So when, when we, when I started this project five years ago, the, the approach we had was go through all the scientific evidence ever published on health and longevity, try to find the interventions that have the best evidence, uh, for effect size, and then we just went down the list from top performing on down. So of course you start with, uh, exercise, nutrition, uh, you know, um, sleep, and you work your way down to things like hyperbaric oxygen therapy and sauna and then rapamycin, metformin. And so we never actually