#525: Multi-Cancer Early Detection Testing
5/18/202649 min
Cut through the hype of Multi-Cancer Early Detection (MCED) tests and learn how to counsel patients on the real-world utility, false-positive risks, and the "stage shift" debate of these emerging blood assays. We are joined by world-renowned oncologist Dr. Margaret Tempero,UCSF Cancer Early Detection and Interception, to discuss whether these tests are truly ready for clinical prime time.
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Show Segments
- 00:00 Introduction
- 01:57 Current Cancer Screening Programs
- 06:05 Emerging Blood-Based Cancer Tests
- 11:55 Test Characteristics and Limitations
- 18:05 Practical Considerations for Patients
- 25:33 Direct-to-Consumer Testing/Whole Body MRIs
- 36:46 Navigating Positive Test Results
- 45:10 Anxiety and Patient Education
- 47:08 Future Directions in Cancer Screening
- Outro
Credits
- Producer, Writer, Show Notes, Infographic, Cover Art: Molly Heublein MD
- Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP
- Reviewer: Sai S Achi MD,MBA,FACP
- Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
- Technical Production: PodPaste
- Guest: Margaret Tempero, MD
Disclosures
Dr. Tempero reports the following financial relationships:
Grail (research support), Global Bio Access Fund (Advisor), Bristol Myers Squibb (Membership on Advisory Committees or Review Panels, Board Membership, etc.), Astra Zeneca (Membership on Advisory Committees or Review Panels, Board Membership, etc), Immunovia (Membership on Advisory Committees or Review Panels, Board Membership, etc.), Merck (advisory committee), Renovo Rx (advisory committee), Urogen (Advisor). Financial relationships have not ended.
The Curbsiders report no relevant financial disclosures.
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Clips
Transcript preview
First 90 secondsMatthew Watto· Host0:00
Hey, before we get to the show, I wanted to remind you to check out our Patreon at patreon.com/curbsiders. If you haven't signed up yet, sign up now to get ad-free episodes, twice monthly bonus episodes, and a whole bunch of other cool stuff at patreon.com/curbsiders. [electronic sounds] You know, Paul, I started telling everybody the benefits of eating dried grapes.
Paul Williams· Host0:22
[sighs] I don't know, man. Are, w- are we... I don't know. I'm g- I'm trying to force a raisin pun in there.
Matthew Watto· Host0:31
[laughs] I feel, I feel like you could guess this.
Paul Williams· Host0:33
I, yeah, we get there eventually. Yeah, I'm telling you.
Matthew Watto· Host0:35
Paul, it's about raisin awareness. [laughs] And that's what we're...
Paul Williams· Host0:38
[drumbeat] [laughs] So that's, uh... Yeah, I knew, I knew raisin had to be in there. The awareness, that's a nice touch.
Matthew Watto· Host0:42
Paul, you'll notice that's lightly on topic for this evening.
Paul Williams· Host0:45
Sure. No strong words. [laughs] Better than a cancer pun probably. [laughs] [upbeat music] The Curbsiders Podcast is for entertainment, education, and information purposes only, and the topics discussed should not be used solely to diagnose, treat, cure, or prevent any diseases or conditions. For the more the views and statements expressed on this podcast are solely those of those and should not be interpreted to reflect the official policy or position of any entity, aside from possibly Cache Lake Memorial Hospital and its affiliate outreach programs, if indeed there are any. In fact, there are none. Pretty much we aren't responsible if you screw up. You should always do your own homework and let us know when we're wrong.
Matthew Watto· Host1:10
[electronic sounds] [upbeat music] Welcome back to The Curbsiders. I'm Dr. Matthew Frank Watto, here with my great friend, pun lover, and America's primary care physician, Dr. Paul Nelson-Williams. Hi, Paul.
Paul Williams· Host1:27
Hey, Matt. How are you?
Matthew Watto· Host1:28
I'm doing well. I,