#449: I Never Said That - Dr. Tyna Moore on How Her GLP-1 Microdosing Message Was Misunderstood and What She Actually Recommends
6/23/20261 hr 18 min
Today, I’m sitting down with the trailblazing Dr. Tyna Moore, a pioneer in reframing the conversation around GLP-1 medications. Instead of focusing solely on weight loss, Dr. Moore reveals how these powerful molecules can open a critical window to reset our health story—if we’re willing to harness that opportunity wisely.
Episode Timestamps:
Welcome, host introduction, and overview ... 00:00:00
Stigma, marketing, and confusion around GLP-1 use ... 00:05:38
True microdosing vs. standard dosing explained ... 00:08:18
Strength training as essential during GLP-1 therapy ... 00:12:06
GLP-1 medications as windows of opportunity for health resets ... 00:13:24
Risks of extreme thinness and frailty for longevity ... 00:15:11
Why metabolic health matters at every age ... 00:20:56
PCOS renamed as a metabolic disease ... 00:26:07
Senescence, exercise, and aging ... 00:28:10
Dr. Tyna Moore’s GLP-1 research and patient findings ... 00:30:34
GLP-1s reveal deeper metabolic issues ... 00:37:28
Differentiating semaglutide, tirzepatide, retatrutide ... 00:39:41
Liver fat, lean mass loss, and weight regain challenges ... 00:43:59
Personalized dosing, side effects, and patient variability ... 00:46:53
Digestive health, SIBO, and supporting GLP-1 users ... 00:52:37
Lab monitoring and practical implementation ... 01:01:04
Immune impacts, senescence, and metabolic improvements ... 01:02:29
Lifestyle first: exercise, peptide stacking, and fundamentals ... 01:10:49
Cautious optimism for the future of GLP-1s ... 01:12:08
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Transcript preview
First 90 secondsNathalie Niddam· Host0:00
[upbeat music] Welcome to Longevity. I'm your host, Natalie Needham. I'm a nutritionist, a human potential and epigenetic coach, and I created this podcast to bring you the latest ways to take control of your health and longevity. We cover it all, from new technology and ancestral health practices, to personalized interventions, and a very special interest of mine, peptides and bioregulators. Enjoy the show. Welcome back to the show. I'm Natalie Needham, your host. Question for you: What if the real opportunity with GLP-1s isn't weight loss? Dr. Tina Moore argues that these medications can create a window to rewrite your health story, but only if you use that opportunity wisely. We talk about everything from inflammation and autoimmune conditions, to why muscle mass matters so much more than fitting into a smaller pair of jeans. And yes, there is an unexpectedly passionate discussion about building a better body for longevity. This is a conversation you are going to love. Dr. Tina Moore is... Well, she's, I think she was probably one of the first people that's really started this conversation on the microdosing for different benefits than weight loss with the GLPs. Uh, so I think you guys are really gonna enjoy this. Now next up, I'll thank a couple of the sponsors who make this podcast possible, and then we get to dive in together. If you've been a regular listener to this podcast for the past few years, you're